abstract：BACKGROUND:Linear endobronchial ultrasound (EBUS) allows real-time guidance of transbronchial needle aspiration of thoracic structures and has become an increasingly important diagnostic tool for chest physicians. Little has been published about the learning experience of operators with this technology. The purpose of ...

journal_title：Chest

authors： Wahidi MM,Hulett C,Pastis N,Shepherd RW,Shofer SL,Mahmood K,Lee H,Malhotra R,Moser B,Silvestri GA

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The clinical course of idiopathic pulmonary fibrosis (IPF) is characterized by progressive decline in lung function and eventual mortality. We sought to determine if future declines in pulmonary function, mortality, or both can be predicted from prior trends in pulmonary function tests (PFTs). METHODS:Data ...

journal_title：Chest

authors： Schmidt SL,Tayob N,Han MK,Zappala C,Kervitsky D,Murray S,Wells AU,Brown KK,Martinez FJ,Flaherty KR

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Clinical practice guidelines recommend enteral over parenteral nutrition in critical illness and do not recommend early initiation. Few data are available on parenteral nutrition use or timing of initiation in the ICU or how this use may have changed over time. METHODS:We used the Project IMPACT database to...

journal_title：Chest

authors： Gershengorn HB,Kahn JM,Wunsch H

更新日期：2014-03-01 00:00:00

abstract：:Targeted temperature management (TTM) has been investigated experimentally and used clinically for over 100 years. The initial rationale for the clinical application of TTM, historically referred to as therapeutic hypothermia, was to decrease the metabolic rate, allowing the injured brain time to heal. Subsequent rese...

journal_title：Chest

authors： Perman SM,Goyal M,Neumar RW,Topjian AA,Gaieski DF

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Some of the challenges in the delivery of high-quality end-of-life care in the ICU include the variability in the characteristics of patients with certain illnesses and the practice of critical care by different specialties. METHODS:We examined whether ICU attending specialty was associated with quality of ...

journal_title：Chest

authors： Kross EK,Engelberg RA,Downey L,Cuschieri J,Hallman MR,Longstreth WT Jr,Tirschwell DL,Curtis JR

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:COPD is accepted to be a multicomponent disease with various comorbidities. To our knowledge, the contribution of the GI tract to the systemic manifestation of COPD has never been investigated. This metabolically active organ may experience recurring local oxygen deficits during daily life, leading to distur...

journal_title：Chest

authors： Rutten EPA,Lenaerts K,Buurman WA,Wouters EFM

更新日期：2014-02-01 00:00:00

abstract：:This commentary heralds the recognition in China of a new subspecialty, Pulmonary and Critical Care Medicine, and the first national fellowship training pathway in any medical specialty. Because of striking environmental health-care similarities that existed in the United States, the Chinese medical community decided ...

journal_title：Chest

authors： Qiao R,Rosen MJ,Chen R,Wu S,Marciniuk D,Wang C,CTS-ACCP Pulmonary and Critical Care Medicine Workgroup.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In pulmonary sarcoidosis, the optimal means of quantifying change is uncertain. The comparative usefulness of simple lung function trends and chest radiography remains unclear. We aimed to explore and contrast the disease-monitoring strategies of serial pulmonary function tests (PFTs) and chest radiography c...

journal_title：Chest

authors： Zappala CJ,Desai SR,Copley SJ,Spagnolo P,Sen D,Alam SM,du Bois RM,Hansell DM,Wells AU

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Patients with acute respiratory symptoms still remain a diagnostic challenge. The aim of the study was to evaluate whether focused sonography could potentially diagnose life-threatening conditions missed at the primary assessment in a patient population consisting of admitted patients with acute respiratory ...

journal_title：Chest

authors： Laursen CB,Sloth E,Lambrechtsen J,Lassen AT,Madsen PH,Henriksen DP,Davidsen JR,Rasmussen F

更新日期：2013-12-01 00:00:00

abstract：:Endoscopic lung volume-reduction therapy for emphysema has been associated with therapeutic responses smaller in magnitude and less durable than surgical volume reduction (LVRS). Bronchoscopic emphysematous lung sealant (ELS) therapy has been shown to produce improvements in pulmonary function similar to surgery at 1 ...

journal_title：Chest

authors： Kramer MR,Refaely Y,Maimon N,Rosengarten D,Fruchter O

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The impact of modern therapy on survival in pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) is not clear. We sought to determine associations among commonly used clinical and hemodynamic variables, treatment, and long-term survival in PAH associated with SSc compared with PAH d...

journal_title：Chest

authors： Rubenfire M,Huffman MD,Krishnan S,Seibold JR,Schiopu E,McLaughlin VV

更新日期：2013-10-01 00:00:00

abstract：:A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association c...

journal_title：Chest

authors： Bartsch S,Haouzi P

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The new GOLD (Global Initiative for Chronic Obstructive Lung Disease) strategy recommends use of the COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) scale to assess symptoms in COPD against "risk" as assessed by spirometry or exacerbation frequency. We aimed to determine the concordanc...

journal_title：Chest

authors： Pillai AP,Turner AM,Stockley RA

更新日期：2013-10-01 00:00:00

abstract：:The Resource-Based Relative Value Scale (RBRVS) is fundamentally undermined by the following foundational errors: (1) The full range of office-based evaluation and management (E/M) activities are not captured by the Current Procedural Terminology (CPT) code choices, (2) it places relatively high values on procedural s...

journal_title：Chest

authors： Kumetz EA,Goodson JD

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The longitudinal associations between depression or anxiety and COPD, and their comorbid effect on prognosis, have not been adequately addressed by previous reviews. We aimed to systematically assess these associations to inform guidelines and practice. METHODS:We searched electronic databases for articles ...

journal_title：Chest

authors： Atlantis E,Fahey P,Cochrane B,Smith S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:It is unknown if the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS:We reviewed records from 177 patients with HP...

journal_title：Chest

authors： Mooney JJ,Elicker BM,Urbania TH,Agarwal MR,Ryerson CJ,Nguyen MLT,Woodruff PG,Jones KD,Collard HR,King TE Jr,Koth LL

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:We aimed to evaluate the availability and practice of spirometry, training of technicians, and spirometer features and maintenance in Spain in both primary care (PC) and secondary care (SC) centers. METHODS:We used a nationwide, cross-sectional, 36-item telephone survey of health-care centers in Spain to ta...

journal_title：Chest

authors： López-Campos JL,Soriano JB,Calle M,Encuesta de Espirometría en España (3E) Project.

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:There is significant heterogeneity within the primary graft dysfunction (PGD) syndrome. We aimed to identify distinct grade 3 PGD phenotypes based on severity of lung dysfunction and patterns of resolution. METHODS:Subjects from the Lung Transplant Outcomes Group (LTOG) cohort study with grade 3 PGD within ...

journal_title：Chest

authors： Shah RJ,Diamond JM,Cantu E,Lee JC,Lederer DJ,Lama VN,Orens J,Weinacker A,Wilkes DS,Bhorade S,Wille KM,Ware LB,Palmer SM,Crespo M,Localio AR,Demissie E,Kawut SM,Bellamy SL,Christie JD

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:A pulmonary right-to-left shunt (RLS) carries the risk of cerebral paradoxical embolization and severe neurologic complications. Recognizing patients at risk is important to facilitate appropriate management strategies, but a direct relation between pulmonary shunt size and risk of complications remains cont...

journal_title：Chest

authors： Velthuis S,Buscarini E,van Gent MWF,Gazzaniga P,Manfredi G,Danesino C,Schonewille WJ,Westermann CJJ,Snijder RJ,Mager JJ,Post MC

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Disease progression in COPD is associated with a decline in exercise performance over time. We assessed whether tiotropium might mitigate this by determining its effect on treadmill endurance time (ET) over 2 years. METHODS:This was a randomized, double-blind, placebo-controlled trial of tiotropium, 18 μg d...

journal_title：Chest

authors： Cooper CB,Celli BR,Jardim JR,Wise RA,Legg D,Guo J,Kesten S

更新日期：2013-08-01 00:00:00

abstract：:Unidirectional endobronchial valves, originally studied for potential treatment of emphysema, have emerged as a useful intervention for patients with persistent air leak from the lung. The procedure is accomplished via bronchoscopy in a patient who already has a chest tube in place for management of the air leak. It u...

journal_title：Chest

authors： Kovitz KL,French KD

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Comorbidities can affect disease progression and/or response to treatment in various conditions. Comorbid conditions are prevalent in patients with pulmonary arterial hypertension (PAH); however, their effect on patient outcomes remains unknown. METHODS:We evaluated the effect on functional class (FC), 6-mi...

journal_title：Chest

authors： Poms AD,Turner M,Farber HW,Meltzer LA,McGoon MD

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport in cystic fibrosis (CF). METHODS:To determine whether a to...

journal_title：Chest

authors： Rowe SM,Reeves G,Hathorne H,Solomon GM,Abbi S,Renard D,Lock R,Zhou P,Danahay H,Clancy JP,Waltz DA

更新日期：2013-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) isolation from clinical specimens is the standard for TB diagnosis. Positive MTB cultures are rarely questioned, but false-positive culture rates range from 2% to 4%. In December 2011, two smear-negative, culture-positive TB cases were reported to the Oklahoma State Department of Healt...

journal_title：Chest

authors： Johnson MG,Lindsey PH,Harvey CF,Bradley KK

更新日期：2013-07-01 00:00:00

abstract：:Pill aspiration represents a unique type of foreign body aspiration requiring a distinct diagnostic and therapeutic approach. In many cases, the "foreign body" itself may no longer be present, whereas the airway manifestations may persist for months to years. Limited data exist to guide management decisions. We report...

journal_title：Chest

authors： Kinsey CM,Folch E,Majid A,Channick CL

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The natural history of flock worker's lung (FWL) and longitudinal lung function changes in nylon flock-exposed workers have not been well characterized. METHODS:Symptoms, pulmonary function testing, and chest radiographs from five index cases, subsequent case referrals, and screened employees of a flocking ...

journal_title：Chest

authors： Turcotte SE,Chee A,Walsh R,Grant FC,Liss GM,Boag A,Forkert L,Munt PW,Lougheed MD

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Studies of the impact of respiratory muscle training (RMT) on central neurodegenerative pathologies have been aimed at improving pulmonary function. However, there is no certainty about the effectiveness of RMT in patients affected by these groups of disorders. The purpose of this review was to assess the ev...

journal_title：Chest

authors： Reyes A,Ziman M,Nosaka K

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:National spirometric surveillance data in the United States were last collected during 1988-1994. The objective of this study was to provide current estimates for obstructive and restrictive impairment of lung function and to examine changes since 1988-1994. METHODS:We used data from 14,360 participants age...

journal_title：Chest

authors： Ford ES,Mannino DM,Wheaton AG,Giles WH,Presley-Cantrell L,Croft JB

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Sleep-disordered breathing (SDB) may promote an increase in cardiac workload early after acute myocardial infarction (AMI). We tested the hypothesis that in the early phase after AMI, SDB is associated with increased 24-h arterial BP, heart rate (HR), and, thus, cardiac workload. METHODS:In this prospective...

journal_title：Chest

authors： Hetzenecker A,Buchner S,Greimel T,Satzl A,Luchner A,Debl K,Husser O,Hamer OW,Fellner C,Riegger GAJ,Pfeifer M,Arzt M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:COPD and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform the selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive the...

journal_title：Chest

authors： Herrin MA,Feemster LC,Crothers K,Uman JE,Bryson CL,Au DH

更新日期：2013-05-01 00:00:00

abstract：:Chronic pulmonary thromboembolism (CPE) is a challenging diagnosis for clinicians. It is an often-forgotten diagnosis and can be difficult to detect and easily misdiagnosed. The radiologic features on CT pulmonary angiography are subtle and can be further compounded by pathologic mimics and unusual findings observed w...

journal_title：Chest

authors： Wijesuriya S,Chandratreya L,Medford AR

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Correctly staging lung cancer is important because the treatment options and prognosis differ significantly by stage. Several noninvasive imaging studies and invasive tests are available. Understanding the accuracy, advantages, and disadvantages of the available methods for staging non-small cell lung cancer...

journal_title：Chest

authors： Silvestri GA,Gonzalez AV,Jantz MA,Margolis ML,Gould MK,Tanoue LT,Harris LJ,Detterbeck FC

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Physicians are often asked about complementary therapies by patients with cancer, and data show that the interest in and use of these therapies among patients with cancer is common. Therefore, it is important to assess the current evidence base on the benefits and risks of complementary therapies (modalities...

journal_title：Chest

authors： Deng GE,Rausch SM,Jones LW,Gulati A,Kumar NB,Greenlee H,Pietanza MC,Cassileth BR

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The incidence and outcomes of disseminated intravascular coagulation (DIC) are incompletely defined. Therefore, we aimed to evaluate the trends in incidence and outcomes of critically ill patients with DIC. METHODS:We conducted a population-based, retrospective cohort study evaluating consecutively admitted...

journal_title：Chest

authors： Singh B,Hanson AC,Alhurani R,Wang S,Herasevich V,Cartin-Ceba R,Kor DJ,Gangat N,Li G

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare disease with a predilection for young women that is associated with right ventricular failure and premature death. PAH can complicate pregnancy with hemodynamic instability or sudden death during parturition and postpartum. Our aim was to examine the impact of ...

journal_title：Chest

authors： Duarte AG,Thomas S,Safdar Z,Torres F,Pacheco LD,Feldman J,deBoisblanc B

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Pulmonary exacerbations in cystic fibrosis (CF) contribute to the burden of disease, with a negative impact on quality of life, costs, and lung function. Our aim was to evaluate whether exacerbations, defi ned by antibiotic use, were triggered by daily fl uctuations in air pollution. METHODS:In a case-cross...

journal_title：Chest

authors： Goeminne PC,Kiciński M,Vermeulen F,Fierens F,De Boeck K,Nemery B,Nawrot TS,Dupont LJ

更新日期：2013-04-01 00:00:00

abstract：:Oxygen therapy is an integral part of the treatment of critically ill patients. Maintenance of adequate oxygen delivery to vital organs often requires the administration of supplemental oxygen, sometimes at high concentrations. Although oxygen therapy is lifesaving, it may be associated with deleterious effects when a...

journal_title：Chest

authors： Budinger GRS,Mutlu GM

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a highly prevalent disorder that has been associated with an increased risk for cardiovascular morbidity, even in children. However, not all children with OSA manifest alterations in endothelial postocclusive hyperemia, an endothelial nitric oxide synthase (eNOS)-dependent re...

journal_title：Chest

authors： Kheirandish-Gozal L,Khalyfa A,Gozal D,Bhattacharjee R,Wang Y

更新日期：2013-04-01 00:00:00

abstract：:The solitary pulmonary nodule (SPN) is frequently encountered on chest imaging and poses an important diagnostic challenge to clinicians. The differential diagnosis is broad, ranging from benign granulomata and infectious processes to malignancy. Important concepts in the evaluation of SPNs include the definition, mor...

journal_title：Chest

authors： Patel VK,Naik SK,Naidich DP,Travis WD,Weingarten JA,Lazzaro R,Gutterman DD,Wentowski C,Grosu HB,Raoof S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Rhinovirus (RV)-induced pulmonary exacerbations are common in cystic fibrosis (CF) and have been associated with impaired virus clearance by the CF airway epithelium in vitro. Here, we assess in vivo the association of RV prevalence and load with antiviral defense mechanisms, airway inflammation, and lung fu...

journal_title：Chest

authors： Kieninger E,Singer F,Tapparel C,Alves MP,Latzin P,Tan HL,Bossley C,Casaulta C,Bush A,Davies JC,Kaiser L,Regamey N

更新日期：2013-03-01 00:00:00